2006-2007

Autumn Quarter, 2006
  • J. Enrique Rozengurt, DVM, PhD
  • Department of Medicine and Molecular Biology Institute
    CURE: Digestive Diseases Research Center
    David Geffen School of Medicine
    University of California, Los Angeles
    Signaling through the PKC/PKD phosphorylation cascade
      

  • Huaxi Xu, PhD
  • Center for Neurosciences and Aging
    Burnham Institute for Medical Research
    Intracellular trafficking and proteolytic processing of Alzheimer's beta-amyloid precursor protein
     
  • Lawrence A. Quilliam, PhD
  • Department of Biochemistry and Molecular Biology
    Walther Oncology Center
    Indiana University School of Medicine
    RA tale of two ras proteins: cell signaling and biological functions of the Rap1A and Rheb GTPases.  This talk was sponsored by the Committees on Molecular Medicine and Cell Physiology.

  • Asma Nusrat, MD
  • Department of Pathology and Laboratory Medicine
    Emory University
    Apical junction complex: A dynamic kiss that regulates epithelial differentiation and barrier function
     
  • Michael B. Koval, PhD 
  • Division of Pulmonary, Allergy, and Critical Care Medicine
    Emory University School of Medicine

    Control of gap junction protein trafficking and assembly
     
  • Michael B. Dwinell, PhD
  • Department of Microbiology and Molecular Genetics
    Medical College of Wisconsin
    Chemokine regulation of the mucosal innate immune barrier

  • Timothy A. Ryan, PhD
  • Department of Biochemistry
    Weill Medical College of Cornell
    Deconstructing the synaptic vesicle cycle
  • Zhuohua Zhang, PhD
  • Burnham Institute for Medical Research
    Pathogenic mechanisms of Parkinson's disease

  • Henrik G. Dohlman, PhD
  • Department of Biochemistry and Biophysics
    University of North Carolina
    G protein signaling at the endosome
  • Juan C. Saez, PhD
  • Department of Physiological Sciences
    Pontificia Universidad Catolica de Chile
    Molecular mechanisms underlying opening and closure of connexin43 based hemichannels
Winter Quarter, 2007
  • Michael P. Blanton, PhD
  • Department of Pharmacology and Neuroscience
    Texas Tech University Health Sciences Center
    Affinity-purification and structural studies of ligand-gated ion channels (alpha4beta2, alpha4beta4, alpha3,beta4, 5-HT3P)
     
  • Robert Nakamoto, PhD
  • Department of Molecular Physiology and Biological Physics
    University of Virginia
    Coupling chemistry and rotation in the ATP synthase
     
  • Jeffrey Matthews PhD
  • Department of Surgery
    University of Chicago
    The third way: Plasma membrane dynamics and the regulation of epithelial transport and barrier function
  • William E. Balch, PhD
  • Department of Cell Biology
    The Scripps Research Institute
    Protein misfolding and folding in the exocytic pathway
     
  • Nanduri Prabhakar, PhD
  • Department of Medicine
    University of Chicago
    Machinery for O2 sensing: Chemoreflexes in health and disease. This talk was sponsored by the Committee on Neurobiology and Committee on Cell Physiology.
  • James Trimmer, PhD
  • Department of Pharmacology
    University of California, Davis
    Activity-dependent regulation of neuronal ion channels by bidirectional changes in phosphorylation state
     
  • Jose A. Esteban, PhD
  • Department of Pharmacology
    University of Michigan
    Molecular machinery for the transport of glutamate receptors at synapses
     
  • Thomas M. Lincoln, PhD
  • Department of Physiology
    University of South Alabama College of Medicine
    Cyclic GMP and smooth muscle cell gene expression: Is it pro- or anti-atherogenic?
  • David Stephens, PhD
  • Department of Biochemistry
    University of Bristol
    Organization of secretory cargo export from the endoplasmic reticulum
  • David A. Ostrov, PhD
  • Department of Pathology, Immunology and Laboratory Medicine
    University of Florida College of Medicine
    High-throughput structure-based selection of novel MLCK inhibitors
Spring Quarter, 2007
  • Itzchak Parnas and Hanna Parnas, PhD
  • Department of Neurobiology
    The Hebrew University
    The chemical synapse goes electric- Ca2+ and voltage sensitive GPCRs
     control neurotransmitter release. 
    This talk is sponsored by the Committee on Cell Physiology and Committee on Neurobiology.

  • Clark Wells, PhD
  • Department of Biochemistry and Molecular Biology
    Indiana University School of Medicine

    Maintaining apical polarity in simple epithelia
     
  • Richard D. Minshall, PhD
  • Department of Pharmacology and Anesthesiology
    University of Illinois at Chicago
    Src regulation of caveolae-mediated transport in pulmonary microvascular endothelial cells

  • Ivan Robert Nabi, PhD
  • Department of Cellular and Physiological Sciences
    University of British Columbia
    Caveolin-1, raft-dependent endocytosis and breast cancer
     
  • Alaa El-Husseini, PhD
  • Department of Psychiatry
    University of British Columbia
    Protein trafficking at nascent neuronal contacts
     
  • Jon Houtman, PhD
  • Department of Microbiology
    University of Iowa
    Investigating the activation and function of the adaptor protein LAT
     
  • Steve M. Sine, PhD
  • Department of Physiology and Biophysics
    Mayo Clinic College of Medicine
    Structural bases of gating and ion flow through nicotinic acetylcholine receptors
     
  • Nicholas C. Spittzer, PhD
  • Neurobiology Section
    Division of Biological Sciences
    University of California, San Diego

    Activity-dependent transmitter specification and receptor selection in neuronal development
     
  • Paul A. Insel, MD
  • Department of Pharmacology and Medicine
    Medical Scientist Training Program
    University of California, San Diego

    Lipid raft/caveolar microdomains and GPCR signaling

2005-2006

Autumn Quarter, 2005
  • Ratnesh Lal, PhD
  • Neuroscience Research Institute
    University of California at Santa Barbara
    Amyloid ion channels: A common structural link for protein misfolding diseases. A paradigm shift for our understanding of degenerative diseases

  • Graduate student presentations: William Lin, Brian Rash
  •  
  • Olaf S. Andersen, MD
  • Department of Physiology and Biophysics
    Weill Medical College of Cornell University
    Lipid bilayers as allosteric regulators of membrane protein function
     
  • Kathleen W. Kinnally, PhD
  • Department of Basic Sciences
    New York University College of Dentistry
    Regulation of the mitochondrial apoptosis-induced channel, MAC, and intrinsic apoptosis by Bc1-2 family proteins
     
  • Graduate student presentations: Pamela Bergson, Matthew Clark

  • Wolfgang Dostmann, MD, PhD
  • Department of Pharmacology
    University of Vermont College of Medicine
    NO more cGMP
     
  • Hugh A. Pearson, PhD 
  • Institute of Membrane and Systems Biology
    University of Leeds
    Proteins, plaques and pores: The role of ion channels in Alzheimer's disease
    (This talk is co-sponsored by the Institute for Molecular Pediatric Sciences)
     
  • Carole Banka, PhD
  • Vascular Biology and Cancer Divisions
    Women's Health Research
    La Jolla Institute for Molecular Medicine
    A mouse model of menopause and peri-menopause: Implications for obesity and atherosclerosis

  • Graduate student presentations: Bruce Herring, Tal Levin

  • Zorina Galis, PhD
  • Atherosclerosis, Lilly Cardiovascular Discovery
    Eli Lilly and Company
    Indiana University
    Molecular driver of vascular remodeling
Winter Quarter, 2006
  • Mark A. Kay, PhD
  • Departments of Pediatrics and Genetics
    Stanford University
    Gene therapy for hemophilia and RNAi approaches for hepatitis infection
     
  • Joyce Bischoff, PhD
  • Department of Surgery, Children's Hospital Boston
    Harvard Medical School and Vascular Biology Program
    Endothelial progenitor cells for cardiovascular tissue engineering
     
  • Eduardo Perozo, PhD
  • Institute for Molecular Pediatric Science
    and Department of Biochemistry and Molecular Biology
    University of Chicago
    Molecular determinants of gating at the K+ channel selectivity filter
     
  • Graduate student presentations: Tom Hummer, Katie Bittner
  • Keith Nehrke, PhD
  • Department of Medicine, Nephrology Unit
    University of Rochester Medical Center
    The nematode C. elegans as a platform for integrative physiology
     
  • William Zagotta, PhD
  • Department of Physiology and Biophysics
    University of Washington
    Molecular mechanisms of gating ion channels by cyclic nucleotides
  • Graduate student presentations: Mazen Kheirbek, Robert Mitchum
  • Yukiko Goda, PhD
  • MRC Cell Biology Unit and Laboratory for Molecular Cell Biology
    University of London
    Synapse regulation across the cleft and between boutons
     
  • Zorina Galis, PhD
  • Atherosclerosis, Lilly Cardiovascular Discovery
    Eli Lilly and Company
    Indiana University
    Molecular driver of vascular remodeling
     
  • Nickolai Dulin, PhD
  • Pulmonary and Critical Care/Medicine
    University of Chicago
    Mitogenic signaling of purinergic receptors in vascular smooth muscle cells
    (This talk is co-sponsored by the CMM Faculty Seminar)
  • Graduate student presentations: Gina Elsen, Atul Mallik
  • Michael F. Goy, PhD
  • Department of Cell and Molecular Physiology
    University of North Carolina
    Are the gut and the kidney on speaking terms? ...Evidence for an intestinal natriuretic peptide
Spring Quarter, 2006
  • T.S. Reese, MD
  • NINDS/NIH
    Molecular architecture of the post synaptic density

  • Graduate student presentations: Michael Carroll, Mike Iacoviello
  •  
  • Robert S. Freeman, PhD
  • Department of Pharmacology and Physiology
    University of Rochester Medical Center
    A role for the HIF prolyl hydroxylase EGLN3 in neuronal cell death
     
  • Adriano Marchese, PhD
  • Department of Pharmacology
    Stritch School of Medicine
    Loyola University chicago
    Regulation of the chemokine receptor CXCR4 by the E3 ubiquitin ligase AIP4/itch

  • Graduate student presentations: Sunday Francis, Liseth Parra
  •  
  • Fred Maxfield, PhD
  • Department of Biochemistry
    Weill Medical College of Cornell University
    Intracellular trafficking and distribution of lipids and cholesterol
     
  • Dora M. Kovacs, PhD
  • Department of Neurology
    Massachusetts General  Hospital
    Harvard Medical School

    BACE1 regulates voltage-gated sodium channel levels and activity
     
  • Kathy K. Griendling, PhD
  • Department of Medicine/Division of Cardiology
    Emory University School of Medicine
    NADPH oxidases and vascular diseases
     
  • Graduate student presentations: Hilary Bierman, Ana Mrejeru
  •  
  • Stanley Thayer, PhD
  • Department of Pharmacology
    University of Minnesota
    Modulation of Ca2+ clearance in neurons: signaling and survival
     
  • Paul Forscher, PhD
  • Department of Molecular, Cellular and Developmental Biology
    Yale University
    Molecular dynamics of guided axon growth
     
  • Harish C. Pant, PhD
  • Laboratory of Neurochemistry
    NIH/NINDS
    Role of cyclic dependent kinase 5 (Cdk5) in nervous system function
  •   Graduate student presentations: Douglas Stoller, Jake Reimer
  •   Graduate student presentations: Jessica Loweth, Derek Zaraza

2004-2005

Autumn Quarter, 2004
  • Pin-Lan Li, MD, PhD
  • Department of Pharmacology and Toxicology
    Medical College of Wisconsin
    Cyclic ADP-ribose Ca2+ signaling and its redox regulation in arterial smooth muscle
     
  • Donald Bers, PhD
  • Department of Physiology
    Loyola University Chicago
    Ca regulation in cardiac myocytes, alterations in heart failure
     
  • Piers Nash, PhD
  • Ben May Institute for Cancer Research
    University of Chicago
    Molecular protein interaction domains in signal transduction
     
  • John A. Hammer, III, PhD
  • Section of Molecular Cell Biology
    Laboratory of Cell Biology
    National Institutes of Health
    Using mouse coat color genetics to decipher motor protein: Organelle interactions
     
  • Joel Swanson, PhD
  • Department of Microbiology and Immunology
    University of Michigan Medical School
    The coordination of signaling during phagocytosis in macrophages
     
  • James T. Stull, PhD
  • Department of Physiology
    University of Texas Southwestern Medical Center at Dallas
    Ca2+-dependent signaling through myosin phosphorylation
     
  • Meyer Jackson, PhD
  • Department of Physiology
    University of Wisconsin Medical School

    Molecular structure-function relations in the fusion pore of Ca-triggered exocytosis
     
  • Steve Cannon, MD, PhD 
  • Department of Neurology
    University of Texas Southwestern Medical Center
    Slow inactivation of voltage-gated Na channels: What we know and why you should care
     
  • Francis J. Miller, Jr., MD
  • Department of Internal Medicine
    University of Iowa
    Role of vascular smooth muscle cell Nox in atherosclerosis 
Winter Quarter, 2005
  • Nicholas G. Davis, PhD
  • Department of Pharmacology
    Wayne State University
    Protein palmitoylation: Enzymes and proteomes
     
  • Ursula Seidler, MD
  • Department of Gastroenterology, Hepatology and Endocrinology
    Hanover Medical School
    The emerging role of PDZ-domain binding proteins in the regulation of intestinal ion transport
     
  • Helen Raybould, PhD
  • Department of Anatomy, Physiology and Cell Biology
    UC Davis School of Veterinary Medicine
    Sensory transduction in the intestine: Transporters and channels
     
  • Mark L. Harlow, PhD
  • Department of Neurobiology
    Stanford University
    The structure of active zone material and the lumen of synaptic vesicles as revealed by electron microscope tomography
  • Graduate student presentations: Jim Bowen, Brian Rash
  • Peter Gillespie, PhD
  • Oregon Hearing Research Center and Vollum Institute
    Oregon Health and Science University
    Molecules of mechanical transduction by hair cells
     
  • R.K. Rao, PhD
  • Department of Physiology
    University of Tennessee Health Science Center
    Epithelial tight junctions, permeability, and protein phosphorylation
  • Graduate student presentations: Will Lin, Heather Walsh
  • Edwin R. Chapman, PhD
  • Department of Physiology
    University of Wisconsin

    Modes and mechanisms of exocytosis
Spring Quarter, 2005
  • Kenneth R. Chien, MD, PhD
  • UCSD Department of Medicine and the Salk Institute
    University of California at San Diego
    Institute of Molecular Medicine

    Islet-1 cardiac progenitors in development and disease
    This talk is co-sponsored by the Committee on Molecular Medicine & Cardiovascular Sciences Training Program. 
  • Graduate student presentations: Hiliary Bierman, Jake Reimer
  • Theodore R. Cummins, PhD 
  • Department of Pharmacology and Toxicology
    Stark Neurosciences Research Institute
    Indiana University School of Medicine
    Sodium channels and the molecular pathophysiology of pain
  • Theodore R. Cummins, PhD 
  • Department of Pharmacology and Toxicology
    Stark Neurosciences Research Institute
    Indiana University School of Medicine
    Sodium channels and the molecular pathophysiology of pain
  • Andrew Escayg, PhD
  • Department of  Human Genetics
    Emory University

    A genetic approach to understanding the mechanism of epilepsy: Human sodium channel mutations and mouse models
     
  • William P. Schilling, PhD
  • Rammelkamp Center for Education and Research
    Department of Physiology and Biophysics
    Case Western Reserve University School of Medicine

    Mammalian TRPC channel proteomics 
     
  • Deepak Srivastava, MD
  • Departments of Pediatrics and Molecular Biology
    University of Texas Southwestern Medical Center

    Building blocks of the heart: Implications for human disease
  • Graduate student presentations: Mike Iacoviello, Tal Levin
  • Vivek Malhotra, D.Phil.
  • Department of Cell and Development Biology
    University of California at San Diego

    Formation of transport carriers and regulating mitotic progression from the Golgi apparatus
     
  • Yuji Mishina, PhD
  • Molecular Developmental Biology Section
    Laboratory of Reproductive and Developmental Toxicology
    National Institute of Environmental Health Sciences/NIH
    Functional analyses of BMP signaling during mesodermal patterning in the mouse
     
  • Daniel Klionsky, PhD
  • Life Sciences Institute
    University of Michigan

    How to live longer, healthier, dementia-free life through autophagy
  • George M. Langford, PhD
  • Department of Biological Sciences
    Dartmouth College

    Axonal/dendritic transport, synaptic plasticity, myosin-V and the actin cytoskeleton
  • Graduate student presentations: Mazen Kheirbek, Bill Thistlethwaite
  • Jochen Prehn, PhD
  • Department of Physiology and RCSI Neuroscience Research Centre
    Royal College of Surgeons in Ireland

    Control of cell death by BH3-only proteins

  • Graduate student presentations: Ryan Mastro, Jessica Loweth

2003-2004
Autumn Quarter, 2003
  • Anne Moon, MD, PhD
  • Department of Pediatrics, Neurobiology and Anatomy
    University of Utah
    Embryonic signaling pathways that guide cardiovascular development and prenatal circulation: The Role of FGF8
     
  • Sean P. Colgan, PhD
  • Department of Anesthesiology and Perioperative Medicine
    Brigham and Women's Hospital and Harvard Medical School
    Hypoxia-inducible factor-1 in mucosal inflammation
     
  • John T. Williams, PhD
  • Vollum Institute
    Oregon Health Sciences University
    Receptor-mediated release of calcium from intracellular stores in dopamine neurons
     
  • Graduate student presentations: Pamela Bergson, Megan McNulty

  • Ingo Greger, PhD
  • MRC - Laboratory of Molecular Biology
    Cambridge University
    A novel role for the Q/R editing site in AMPA receptor trafficking
     
  • Paul A. Welling, MD
  • Department of Physiology
    University of Maryland School of Medicine
    Molecular mechanisms of Kir channel defects in Bartter's disease
     
  • Jack H. Kaplan, PhD, FRS
  • Department of Biochemistry and Molecular Genetics
    University of Illinois at Chicago
    Pumping ions: Molecular analysis of the Na, K-ATPase
     
  • Jan Sap, PhD
  • Department of Pharmacology
    New York University School of Medicine
    Insights into neuronal signaling and migration from studies on receptor protein tyrosine phosphatase alpha (RPTAa)
     
  • Microscopy Mini-Symposium
    Stefan W. Hell, PhD
    NanoBiophotonics Department
    Max Planck Institute of Biophysical Chemistry
    Far-field fluorescence nanoscopy

    John W. Sedat, PhD
    Department of Biochemistry and Biophysics
    University of California, San Francisco
    New directions for light microscopy: First biological results

    Watt W. Webb ScD
    School of Applied and Engineering Physics
    Cornell University
    Microscopic to nanoscopic probing the molecular dynamics of life

  • Indira M. Raman, PhD
  • Department of Neurology and Physiology
    Northwestern University
    High-frequency signaling at the Purkinje to cerebellar nuclear cell synapse: Ionic and synaptic mechanisms
Winter Quarter, 2004
  • Graduate student presentations: Rob Guzy, Ryan Mastro
  • Gerry Oxford, PhD
  • Stark Neurosciences Research Institute
    Indiana University School of Medicine
    Dopamine receptors and potassium channels: How many are too many? And so what?
     
  • Cecilia Giulivi, PhD
  • Department of Chemistry
    University of Minnesota
    Mitochondrial nitric-oxide synthase: A novel regulation of cellular oxygen consumption
     
  • Sanford M. Simon, PhD
  • Laboratory of Cellular Biophysics
    The Rockefeller University
    The dynamics of molecules at the cell surface during exo and endocytosis
     
  • Graduate student presentations: William Lin, Rose Mastracci
  • Asrar Malik, PhD
  • Department of Pharmacology
    University of Illinois College of Medicine
    Caveolae trafficking and transcytosis: Regulation of endothelial barrier function
     
  • Joseph Bryan, PhD
  • Department of Molecular and Cellular Biology
    Baylor College of Medicine
    Hypoglycemic agents, sulfonylurea receptors and ATP-sensitive K+ channels
     
  • Jie Chen, PhD
  • Department of Cell and Structural Biology
    University of Illinois at Urbana-Champaign
    mTOR signaling in cell growth and differentiation
     
  • Michael Wm. Roe, PhD
  • Department of Medicine/Endocrinology Section
    University of Chicago
    Imaging intracellular calcium with fluorescent biosensors
     
  • Brian O'Rourke, PhD
  • Institute for Molecular Cardiobiology
    The Johns Hopkins University
    Mitochondria as biological oscillators
     
  • Stephen Keely, PhD
  • Department of Medicine
    University of California, San Diego
    The epidermal growth factor receptor in regulation of intestinal epithelial secretion
Spring Quarter, 2004
  • Joseph A. Beavo, PhD
  • Department of Pharmacology
    University of Washington
    Regulation of cyclic nucleotide metabolism
     
  • Winfried Denk, PhD
  • Max-Planck-Institute for Medical Research
    Heidelberg/Germany
    Imaging circuits: Will signals and wiring tell us the alogrithms?
     
  • John C. Hutton, PhD
  • Barbara Davis Center for Childhood Diabetes
    University of Colorado Health Sciences Center
    Fishing with worms in diabetes: What C. elegans has taught us about insulin granule biogenesis and traffick
     
  • Harry Ischiropoulos, PhD
  • Department of Pediatrics, Biochemistry and Biophysics
    Children's Hospital of Philadephia
    Oxidative and nitrative stresses in Parkinson's disease: Cause, effect or association?
     
  • Daniel R. Storm, PhD
  • Department of Pharmacology
    University of Washington
    Role of calcium regulated adenylyl cyclases in neuroplasticity
     
  • Tarun B. Patel PhD
  • Department of Pharmacology
    Loyola University Medical Center
    Sprouty: A novel regulator of receptor tyrosine kinases
     
  • Graduate student presentations: Matthew Clark, Michael Iacoviello
  •  
  • Phyllis Hanson, MD, PhD
  • Department of Cell Biology and Physiology
    Washington University School of Medicine
    Role of AAA chaperones in membrane trafficking
     
  • Heidi Hamm, PhD
  • Department of Pharmacology
    Vanderbilt University
    G-protein regulation of synaptic transmission
     
  • Philipp E. Scherer, PhD
  • Department of Cell Biology and Medicine
    Diabetes Research and Training Center
    Albert Einstein College of Medicine
    Adipocyte-derived hormones: Relevance for metabolism and cancer
     
  • Alan S. Fanning, PhD
  • Department of Cell and Molecular Physiology 
    University of North Carolina at Chapel Hill
    Regulation of paracellular barrier assembly by the tight junction scaffolding protein ZO-1
     
  • Graduate student presentations: Eric Norstrom 
  • Wei Guo, PhD
  • Department of Biology
    University of Pennsylvania
    Molecular basis of polarized exocytosis
     
  • Graduate student presentations: Chad Grabner, Heather Patel

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