Sleep-disordered breathing with recurrent apneas is a major cause of morbidity and mortality in the U.S. population. Conditions that lead to transient repetitive apnea (cessation of breathing) result in intermittent hypoxia (IH; periodic decreases in arterial PO2). Chronic IH (CIH) results in autonomic abnormalities including elevated sympathetic nerve activity and plasma catecholamines. However, little is known regarding whether CIH also affects the adrenal medulla, an effector organ of the chemoreflex pathway. My overall project is understanding the mechanisms by which CIH affects adrenal medulla function.

GK. Kumar, V Rai, SD. Sharma, DP Ramakrishnan,YJ Peng, D.Souvannakitti, NR. Prabhakar. Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress., The Journal of Physiology, 2006 575:1 229

Napradit P, Pantaewan P, Nimit-arnun N, Souvannakitti D, Rangsin R. Prevalence of overweight and obesity in Royal Thai Army personnel. J Med Assoc Thai. 2007 Feb;90(2):335-40.        

Abstracts

Easton, R. Bartlett, D. Souvannakitti and D.A. Hanck, Window current in voltage gated calcium channels. Experimental Biology. 2007.

D. Souvannakitti .To Review the History of Thai Traditional and Western medicine in Thailand. International Conference, Second Integrated Holistic Health Care and Fifth Bioenergetic Information Medicine, Hawaii, 2005.