Steve Kron, M.D., Ph.D.

Primary:

Associate Professor, Molecular Genetics and Cell Biology

Secondary:

Committee on Genetics
Committee on Cancer Biology
Committee on Cellular and Molecular Physiology
Committee on Molecular Medicine
Committee on Molecular Medicine and The College

Education:

Degree	Year	Institution	Area
BA	1982	University of Pennsylvania	Biochemistry
MSE	1983	University of Pennsylvania	Bioengineering
MD	1990	Stanford University	Medicine
PhD	1990	Stanford University	Cell Biology


Phone:	(773) 834-0250 / Fax: (773) 702-4394 / Lab: (773) 834-0256
E-Mail:	skron@uchicago.edu
Address:	924 E. 57th Street Chicago, IL 60637 JFK R320 Lab: JFK R322
Web page:	http://mgcb.bsd.uchicago.edu/ http://mgcb.bsd.uchicago.edu/faculty/kron/index.html

Research Summary

DNA damage responses; Phosphoproteomics in cell signaling, diagnostics and drug discovery.

The Kron laboratory is a highly collaborative group of cell biologists, geneticists, biochemists and chemists. Our major basic research efforts are directed at 1) dissecting cyclin dependent kinase structure and function in yeast, 2) defining roles for chromatin modifications in DNA damage response, and 3) developing novel mass spectrometry methods for phosphoproteomics and high throughput screening. We also pursue translational projects directed at 1) developing Bcr-Abl assays for diagnostics and antagonists for therapeutics and 2) discovering inhibitors of cellular response to DNA double strand breaks as an approach to radiosensitization.

Selected Publications

Wu, D., Nair-Gill, E., Sher, D.A., Parker, L.L., Campbell, J.M., Siddiqui, M., Stock, W. and Kron, S.J. Assaying Bcr-Abl kinase activity and inhibition in whole cell extracts by phosphorylation of substrates immobilized on agarose beads. Anal. Biochem., 347:67-76, 2005. PubMed Citation

Parker, L.L., Schilling, A.B., Kron, S.J. and Kent, S.B. Optimizing thiophosphorylation in the presence of competing phosphorylation with MALDI-TOF-MS detection. J. Proteome Res., 4:1863-66, 2005. PubMed Citation

Wysocki, R., Javaheri, A., Allard, S., Sha, F., Cote, J. and Kron, S.J. (2005). Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Mol. Cell. Biol., 25:8430-43. PubMed Citation

Parker, L. L., Kurutz, J. W., Kent, S. B. and Kron, S.J. Control of the yeast cell cycle with a photocleavable alpha-factor analogue. Angew Chem. Int. Ed. Engl., 45:6322-5, 2006. PubMed Citation

Javaheri, A., Wysocki, R., Jobin-Robitaille, O., Altaf, M., Cote, J. and Kron, S.J. Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling. Proc. Natl. Acad. Sci. U.S.A., 103:13771-6, 2006. PubMed Citation

Wysocki, R., Javaheri, A., Kristjansdottir, K., Sha, F. and Kron, S.J. CDK Pho85 targets CDK inhibitor Sic1 to relieve yeast G1 checkpoint arrest after DNA damage. Nat. Struct. Mol. Biol., 13:908-914, 2006. PubMed Citation

Updated 9/21/07.