Nickolai O. Dulin, Ph.D.

Primary:

Assistant Professor, Section of Pulmonary and Critical Care Medicine, Department of Medicine

Secondary:

Cancer Research Center
Committee on Cancer Biology
Committee on Molecular Medicine
Committee on Cell Physiology
Education:
Degree Year Institution Area
MS
1987
Moscow State University, Russia
Biology
PhD
1990
  
Moscow State University, Russia
Biology


Phone: (773) 702-5198
E-Mail: ndulin@medicine.bsd.uchicago.edu
Address: AMB M648 (MC 6076)
Web page:
 http://medicine.uchicago.edu/faculty_profile/faculty_profile.asp?empl_id=7224

Research Summary

Regulation of cell growth and differentiation through G-protein signalling
Dr. Nickolai Dulin studies the signaling mechanisms controlling growth and differentiation of vascular smooth muscle cells (VSMC) and pulmonary fibroblasts in response to endothelin-1, extracellular ATP and transforming growth factor-beta (TGF-beta). This includes activation of various types of heterotrimeric G proteins, Smad transcription factors, and their modulation by the family of the regulators of G protein signaling (RGS) proteins. His basic, NIH-funded research applies to understanding the pathogenesis of atherosclerosis, restenosis, pulmonary hypertension and pulmonary fibrosis at the molecular/cellular level.

Selected Publications

Dulin, N.O., Sorokin, A., Reed, E., Elliott, S., Kehrl, J.H. and Dunn, M.J. RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11. Mol. Cell. Biol., 19:714-23, 1999.

Dulin, N.O., Pratt, P., Tiruppathi, C., Niu, J., Voyno-Yasenetskaya, T. and Dunn, M.J. Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis. J. Biol. Chem., 275:21317-23, 2000.

Dulin, N.O., Orlov, S.N., Kitchen, C.M., Voyno-Yasenetskaya, T.A. and Miano, J.M. G-protein-coupled-receptor activation of the smooth muscle calponin gene. Biochem. J., 357:587-92, 2001.

Niu, J., Scheschonka, A., Druey, K.M., Davis, A., Reed, E., Kolenko, V., Bodnar, R., Voyno-Yasenetskaya, T., Du, X., Kehrl, J. and Dulin, N.O. RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain. Biochem. J., 365:677-84, 2002.

Hogarth, D.K., Sandbo, N., Taurin, S., Kolenko, V., Miano, J.M. and Dulin, N.O. Dual role of PKA in the phenotypic modulation of vascular smooth muscle cells by extracellular ATP. Am. J. Phys. Cell Physiol., 287:C449-C456, 2004.

Taurin, S., Sandbo, N., Qin, Y., Browning, D. and Dulin, N.O. Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase. J. Biol. Chem., 281(15):9971-9976, 2006.

Taurin, S., Hogarth, K., Sandbo, N., Yau, D.M. and Dulin, N.O. Gbeta-gamma-mediated activation of PKA by endothelin-1 promotes vascular smooth muscle cell hypertrophy through inhibition of glycogen synthase kinase-3.  J. Biol. Chem., 282(27):19518-25, 2007.

Updated 9/25/07.