Michael Roe, Ph.D.


Primary:

Assistant Professor, UN Track
Department of Medicine/Endocrinology Section


Secondary:

Committee on Cellular and Molecular Physiology

Education:

Degree Year Institution Area
BSE   1976
   Duke University   Mechanical Engineering/Materials Science
MS
1982
Duke University
Pathology
PhD
   1986
   University of Vermont   Cell Biology/Pat6hology


Phone: (773) 702-4965
E-Mail: mroe@medicine.bsd.uchicago.edu
Address: AMB M172 (MC 1027)

Web page:		 http://medicine.uchicago.edu/section_pages/endo/index.htm
http://med-www02.bsd.uchicago.edu/faculty_internet/faculty_profile.asp?empl_id=427

Research Summary

Pancreatic beta cell biology and the pathophysiology of Type 1 and Type 2 diabetes mellitus

The primary goal of Dr. Roe's research is to identify and characterize the molecular mechanisms underlying beta cell dysfunction and death associated with diabetes. The concentration of calcium ions in beta cells is precisely and finely regulated by an extensive array of calcium signaling mechanisms. A defect in one or more of these regulatory  mechanisms is likely to have a profound impact on beta cell function and viability. Defining the molecular mechanisms that regulate insulin secretion and beta cell viability is essential for development of new strategies for the treatment and prevention of diabetes.

Selected Publications

Roe, M.W., Worley, J.F., III, Mittal, A.A., Kuznetsov, A., DasGupta, S., Mertz, R.J., Witherspoon, S.M., III, Blair, N., Lancaster, M.E., McIntyre, M.S., Shehee, R., Dukes, I.D., and Philipson, L.H. Expression and function of pancreatic Ã’-cell delayed rectifier K+ channels: Role in stimulus-secretion coupling. Journal of Biological Chemistry, 271:32241-32246, 1996.

Roe, M.W., Worley, J.F., III, Qian, F., Mittal, A.A., Dralyuk, F., Lancaster, M.E., Mertz, R.J., Philipson, L.H., and Dukes, I.D. Characterization of a Ca2+ release-activated nonselective cation current (ICRAN) regulating membrane potential and [Ca2+]i oscillations in transgenically-derived Ã’-cells. Journal of Biological Chemistry, 273:10402-10410, 1998.

Sreenan, S., Mittal, A.A., Dralyuk, F., Pugh, W., Polonsky, K.S., and Roe, M.W. Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans.  Metabolism 49:1579-1587, 2000.

Roe, M.W., Moore, A.L., and Lidofsky, S.D. Purinergic-independent calcium signaling mediates recovery from hepatocellular swelling: Implications for volume regulation. Journal of Biological Chemistry 276:30871-30877, 2001.

Bindokas, V.P., Kuznetsov, A., Screenan, S., Polonsky, K.S., Roe, M.W., and Philipson, L.H. Visualizing superoxide production in normal and diabetic rat islets of Langerhans. Journal of Biological Chemistry, 278:9796-9801, 2003.

Updated 10/1/02.