Julian Solway, M.D.

Primary:

Walter L. Palmer Distinguished Service Professor of Pulmonary and Critical Care Section

Secondary:

Departments of Medicine and Pediatrics
Chair, Committee on Molecular Genetics
Committee on Cellular and Molecular Physiology

Education:

Degree	Year	Institution	Area
BS	1974	Massachusetts Institute of Technology	Electrical Engineering
MD	1978	Harvard University (cum laude)	Medicine
Residency	1978-1981	Brigham and Women's Hospital	Internal Medicine
Fellowship	1981-1983	Brigham and Women's Hospital	Pulmonary Fellowship


Phone:	(773) 702-6790
E-Mail:	jsolway@medicine.bsd.uchicago.edu
Address:	AMB M644 (MC 6026)
Web page:	http://med-www02.bsd.uchicago.edu/faculty_internet/faculty_profile.asp?empl_id=3433

Research Summary

Dr. Solway's laboratory addresses molecular mechanisms underlying airway constrictor hyperresponsiveness in asthma, including 1) Regulation of smooth muscle gene expression (with focus on SRF and GATA5); 2) Evaluation of mutations and mechanisms underlying heritable cholinergic hyperresponsiveness in a kindred of ENU-mutagenized mice; 3) Functional genetics of asthma, (consequences of genetic variations and transcriptional analysis of endobronchial biopsies); 4) Molecular mechanisms that regulate the mechanical plasticity-elasticity (taffy-like vs. rubber band-like) balance in contracted airway smooth muscle.

Selected Publications

Solway, J., Seltzer, J., Samaha, F., Kim, S., Alger, L.E., Niu, Q., Morrisey, E.E., Ip, H.S. and Parmacek, M.S. Structure and expression of a smooth muscle cell-specific gene, SM22-alpha. J. Biol. Chem., 270(2):13460-13469, 1995.

Halayko, A.J., Camoretti-Mercado, B., Forsythe, S.M., Vieira, J.E., Mitchell, R.W., Wylam, M.E., Hershenson, M.B., and Solway, J. Divergent differentiation pathways in cultured airway smooth muscle: Induction of a subset of functionally contractile myocytes. Am. J. Physiol., 276 (Lung Cell. Mol. Physiol. 20):L197-L206, 1999.

Camoretti-Mercado, B., Liu, H.W., Halayko, A.J., Forsythe, S.M., Kyle, J.W., Li, B., Fu, Y., McConville, J., Kogut, P., Vieira, J.E., Patel, N.M,, Hershenson, M.B., Fuchs, E., Sinha, S., Miano, J.M., Parmacek, M.S., Burkhardt, J.K., and Solway, J. Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor. J. Biol. Chem., 275(39):30387-30393, 2000.

Forsythe, S.M., Kogut, P.C., McConville, J.F., Fu, Y., McCauley, J.A., Halayko, A.J., Liu, H.W., Kao, A., Fernandes, D.J., Bellam, S., Fuchs, E., Sinha, S., Bell, G.I., Camoretti-Mercado, B., and Solway, J. Structure and transcription of the human m3 muscarinic receptor gene. Am. J. Resp. Cell Mol. Biol., 26(3):298-305, 2002.

Liu, H.W., Halayko, A.J., Harmon, G.S., McCauley, J.A., Kocieniewski, K., McConville, J., Fu, Y., Forsythe, S.M,, Fernandes, D.J., Kogut, P., Bellam, S., Dowell, M., Churchill, J., Lesso, H., Kassiri, K., Mitchell, R.W., Hershenson, M.B., Camoretti-Mercado, B., and Solway, J. The RhoA/Rho kinase pathway regulates nuclear localization of serum response factor. Am. J. Resp. Cell Mol. Biol., 29(1):39-47, 2003.

Update 9/16/04.