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Elizabeth McNally, M.D., Ph.D.
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Education:
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| Degree | Year | Institution | Area | |||
| BA | 1983 |
Barnard College, Columbia University | Biology/Philosophy | |||
| MS |
1990 |
Albert Einstein College of Medicine | Microbiology and Immunology |
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| PhD | 1990 |
Albert Einstein College of Medicine | Microbiology and Immunology | |||
| MD |
1990 |
Albert Einstein College of Medicine | Medicine |
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| 1993-1996 |
Children's
Hospital and HHMI |
Genetics |
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| Phone: | (773) 702-2672 |
| E-Mail: | emcnally@uchicago.edu |
| Address: | Abbott 506A (MC 0926) |
| Webpage: | http://medicine.uchicago.edu/faculty_profile/faculty_profile.asp?empl_id=4474 |
Research Summary
The genetic and cellular mechanism of muscle degeneration.Dr. McNally studies the genetics of heart and muscle disease. Her laboratory examines mechanisms by which genetic mutations lead to cardiomyopathy, arrhythmias and vascular spasm. Her laboratory studies the dystrophin glycoprotein complex, including the sarcoglycans, which help stabilize the plasma membrane of cardiac and skeletal muscle. The laboratory is also interested in proteins that play a role in membrane repair in skeletal and cardiac muscle and in proteins at the nuclear membrane and their role in cardiac and skeletal muscle function. Her laboratory also studies ATP sensitive potassium channels in cardiovascular stress. Dr. McNally also directs the Cardiovascular Sciences Training Grant.
Selected Publications
Chutkow,
W.A., J.L. Pu, M.T.
Wheeler, J.C. Makielski, C.F. Burant and E.M. McNally. Prinzmetal
like
vasospasm, hypertension and early death result from mutant Sur2 KATP
channels
in mice. J. Clin. Invest., 110:
203-208, 2002.
McNally, E.M. Powerful genes:
Myostatin in the
regulation of human muscle mass. N.
Engl. J. Med.,
350(26):2642-4, 2004.
Doherty,
K.R., A. Cave, D.B. Davis, A.J. Delmonte, A. Posey, J.U. Earley, M.
Hadhazy, and E.M.
McNally.
Normal myoblast fusion requires myoferlin. Development,
132:5565-75, 2005.
Kakkar, R., B. Ye, D.A. Stoller, M. Smelley, N.Q. Shi, K. Galles, M. Hadhazy, J.C. Makielski, and E.M. McNally. Spontaneous coronary vasospasm in KATP mutant mice arises from a smooth muscle-extrinsic process. Circ Res., 98:682-9, 2006.
Allikian, M.J., G. Bhabha, P. Dospoy, A. Heydemann, P. Ryder, J.U. Earley, M.J. Wolf, H.A. Rockman, and E.M. McNally. Reduced lifespan with heart and muscle dysfunction in Drosophila sarcoglycan mutants. Hum. Mol. Gen., (in press).
Updated 9/10/07.